1，尽管遭受种种挫折，他没有丧失信心。
with all the setbacks , he did not lose heart .
2,在任何情况下，都不要灰心，继续努力。
in no case should you lose heart and keep on trying ,
3,校长叫我们在困难的时候不要灰心丧气。
the headmaster told us not to lose heart in time of difficulty
in spite of "尽管" （注意：词短语后面不可以直接接句子，它可以接名词或名词短语。）
for instance：
1，in spite of all his efforts , his debts continued to mount up .
尽管他做了最大的努力，但是他的债务还在继续增加。
2，the arts of China have not declined in spite of Western influence .
虽有西方影响，中国的古老艺术并未因此而衰落。
1.In spite of affection couldn't be better, Taurus still calculates to the money clear.
2.In spite of favorable economic indicators keep coming to the fore, people still feel gloomy.作者: 应春盛 时间: 2011-5-6 12:09
1，不管感情再好，金牛座对于金钱还是算得一清二楚。
In spite of great emotion, the Taurus has a good understanding of money.
2，尽管正面的经济指标不断涌现，但人们仍然一直悲观。
In spite of the positive economic appeared continuously,people still were in pessimism.作者: davis081 时间: 2011-5-6 12:31
1.Taurus is clear-cut to money in spite of good affections.
2.In spite of positive economic indicator continue to bring out,people still continuously pessimistic.作者: shuiyingzi5 时间: 2011-5-7 12:42
1.In spite of the friendship is good,
it will deal with the money problem clearly.
2.In spite of economic is becoming better than before,
people is still pessimistic
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that's great !